Knowledge Graph Explorer - FluxAI Healthcare Demo

Knowledge Graph Explorer

Discover and analyze research connections across medical domains

Filters

ENTITY TYPES

EVIDENCE STRENGTH

TIME PERIOD

FOCUS AREA

Immunotherapy Breast Cancer

AI Research Assistant

I can help discover patterns in your research graph. What would you like to explore?

LEGEND

Disease
Treatment
Biomarker
Gene
Pathway
Strong Evidence
Moderate Evidence
Theoretical Only

Selected Entity

Treatment

Trastuzumab

Monoclonal antibody used to treat HER2-positive breast cancer by targeting the HER2 receptor.

CONNECTED TO

HER2+ Breast Cancer treats
HER2/neu targets
Pertuzumab combined with
Cardiac Function affects

EVIDENCE STRENGTH

Very Strong (Level 1)
87%

KEY SOURCES

Slamon et al. (2001) NEJM

First major trial demonstrating efficacy

Perez et al. (2014) JCO

Long-term cardiac safety data

Von Minckwitz et al. (2017) NEJM

Extended adjuvant therapy benefits

RESEARCH TRENDS

2015 Publications/Year 2022

AI Analysis

Pattern identified: Trastuzumab shows strong connections to HER2+ breast cancer treatment pathways and moderate connections to several emerging biomarkers.

Research gap: Limited studies on potential effectiveness in HER2-low expressing cancers, which represents an opportunity area.

Emerging trend: Increasing research on combining trastuzumab with immune checkpoint inhibitors shows promising preliminary results.

SUGGESTED EXPLORATIONS