Knowledge Graph Explorer

Discover and analyze research connections across medical domains

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Immunotherapy Breast Cancer

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LEGEND

Disease
Treatment
Biomarker
Gene
Pathway
Strong Evidence
Moderate Evidence
Theoretical Only

Selected Entity

Treatment

Trastuzumab

Monoclonal antibody used to treat HER2-positive breast cancer by targeting the HER2 receptor.

CONNECTED TO

HER2+ Breast Cancer treats
HER2/neu targets
Pertuzumab combined with
Cardiac Function affects

EVIDENCE STRENGTH

Very Strong (Level 1)
87%

KEY SOURCES

Slamon et al. (2001) NEJM

First major trial demonstrating efficacy

Perez et al. (2014) JCO

Long-term cardiac safety data

Von Minckwitz et al. (2017) NEJM

Extended adjuvant therapy benefits

RESEARCH TRENDS

2015 Publications/Year 2022

AI Analysis

Pattern identified: Trastuzumab shows strong connections to HER2+ breast cancer treatment pathways and moderate connections to several emerging biomarkers.

Research gap: Limited studies on potential effectiveness in HER2-low expressing cancers, which represents an opportunity area.

Emerging trend: Increasing research on combining trastuzumab with immune checkpoint inhibitors shows promising preliminary results.

SUGGESTED EXPLORATIONS