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Node Details: Type 2 Diabetes Mellitus

Condition

Definition

Type 2 diabetes is a metabolic disorder characterized by high blood glucose due to insulin resistance and relative insulin deficiency. It is associated with obesity, physical inactivity, and genetic factors.

Common Treatments

Metformin SGLT2 Inhibitors GLP-1 Receptor Agonists DPP-4 Inhibitors Sulfonylureas Insulin Therapy

Biomarkers

HbA1c Fasting Blood Glucose Oral Glucose Tolerance Test C-Peptide

Related Conditions

Obesity Hypertension Dyslipidemia Diabetic Retinopathy Diabetic Nephropathy Diabetic Neuropathy

Recent Literature

Effect of SGLT2 Inhibitors on Cardiovascular Outcomes in T2DM

N Engl J Med. 2024;391(2):127-139

Evidence Level: High View

Comparative Effectiveness of GLP-1 RAs and SGLT2 Inhibitors

JAMA. 2023;330(14):1356-1368

Evidence Level: High View

Metformin and All-Cause Mortality in T2DM

Diabetes Care. 2024;47(3):543-551

Evidence Level: Moderate View

View all 127 publications

Knowledge Gaps

Optimal treatment sequence after metformin failure
Predictors of SGLT2 inhibitor response
Long-term cognitive effects of hypoglycemia